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Attempting the Impossible: A 20-Year Journey to Learn the Language of the Brain

A record-breaking media campaign telling the story of the most complicated neuroscience experiment ever attempted: the MICrONS Project

This ground-breaking achievement will help medical science better understand and treat brain diseases, from Alzheimer’s to Parkinson’s, and even neuropsychiatric disorders.

How it all Began: The Origin Story Centered Around a Scientist’s Dream

In the 80s as a university student, Clay Reid read a famous quote by Nobel laureate Francis Crick in the pages of Scientific American that inspired him on the path to tackle one of the most ambitious scientific challenges in history: mapping a portion of the animal brain and all of its electrical firing properties together.

To set the stage, the Editorial and Media team at the Allen Institute produced a high-engagement multimedia story, known as a ‘multiscroll,’ to reveal this opening chapter and how this seven-year scientific journey began.

“It is no use asking for the impossible, such as, say, the exact wiring diagram for a cubic millimeter of brain tissue and the way all its neurons are firing.”

~ Francis Crick, 1916 – 2004

Experience the MultiMedia Story
This image shows a subset of more than 1,000 of the 120,000 neurons reconstructed in the MICRONS project. Each reconstructed neuron is a different random color. A subset of the neurons have been symbolically rendered as glowing to represent the fact that this dataset includes functional recordings from a subset of neurons.

Mission Accomplished: A Stunning Scientific Achievement

Next, we wrote a web story describing the challenge now realized and the painstaking effort it took to get there. From a tiny piece of brain no larger than a grain of sand, scientists uncovered a universe of complexity: half a billion synapses, over 200,000 cells, and four kilometers of axons after producing the largest, most complex wiring diagram of the animal brain to date.

The scientific undertaking took seven years and over a hundred scientists and researchers to complete. It reshaped the scientific landscape of electron microscopy and propels research into brain diseases like Alzheimer’s and Parkinson’s forward.

Read the Story

Video Unveiling MICrONS to the World and its Impact on Human Health

Our multimedia storytellers produced a feature video communicating the importance and impact of this tremendous achievement.

“How could we not want to know what we think with? What are the parts in this part of the brain? How do they interconnect to do their computations? It’s also the part of the brain that goes awry in all sorts of diseases—neurodegenerative diseases, Alzheimer’s, there are all sorts of lesions of the circuits that we’re studying. And I think if you don’t know what are the building blocks and how they connect, it’s hard to think about when it goes wrong.”

~ Clay Reid, M.D., Ph.D.

Lab Notes Digital Brain

To ensure coverage in all mediums, we produced an engaging podcast episode highlighting a unique dimension of this transformational scientific achievement: the use of artificial intelligence to help digitally recreate the brain wiring diagram. The MICrONS dataset also serves as a new source of energy for large language models. In the words of one of the researchers, it is “nuclear fuel” for artificial intelligence that promises to build more trustworthy and interpretable AI models because it is based on real biological data on how the brain actually behaves.

Impact

The media campaign shattered previous records at the Allen Institute. Earned media reached 220 million people in 26 countries on every content except Antarctica.

(Hover over the graphs below for interactive features and to explore the impact.)

See Earned Media Highlights
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Earned Media

297% increase in earned media placements (stories filed) from previous record

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International Media

381% increase in international earned media placements from previous record

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New Media

Secured placements in multiple new media outlets such as newsletters and podcasts

Top-Tier Media

The MICrONS Project was featured by the most prestigious and respected news organizations in the world.

(Click on the logos to read the stories.)

new york times logo
new york times logo

International Media

The campaign’s impact was global. It reached 26 countries and every continent except Antarctica.

Coverage in all Mediums

The MICrONS Project was covered in print, radio, TV, podcast, and digital—leaving no corner of the media ecosystem untouched.


“New Media” Coverage

In response to an ever-changing media landscape where audiences are fragmenting to other sources of information, we targeted influencers, substacks, and newsletters to meet their migration. Our success here resulted in a surge of web traffic, accounting for 10% of our website’s entire traffic volume year to date.

Newsletter Ben Rein (Instagram) Ben Miles (YouTube) Eric Topol (Bluesky) Substack
Newsletter Ben Rein (Instagram) Ben Miles (YouTube) Eric Topol (Bluesky) Substack

Stellar Social Media

The earned media worked synergistically with our social media outreach.

  • Highlighted key points and science details on microblogging platforms (X, Threads, BlueSky)

  • Implemented strategic video carousel on Instagram to keep followers engaged in-app and bring the story to life

  • Promoted earned media placements through imagery instead of linked meta cards to increase reach and engagement

All of these images show a subset of more than 1,000 of the 120,000 brain cells (neuron + glia) reconstructed in the MICRONS project. Each reconstructed neuron is a different random color. In some of the images, a subset of the neurons have been rendered as glowing in different ways to represent the fact that this dataset includes functional recordings from a subset of neurons.
Owned Social Content
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engagement rate
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