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synthetic biology
synthetic biology
engineering cells and organisms to record their own histories, giving science an unprecedented look into how life unfolds.

Cells don't just exist in the present. We’re learning how to record and reconstruct everything they experience as they develop into organisms.
Traditional biology works in snapshots, capturing a frozen moment in a cell or organism's life. But disease doesn't emerge in a single moment. It's a process, unfolding over time through countless molecular and cellular decisions. To truly understand disease, you need to understand that entire process.
The Seattle Hub for Synthetic Biology—a landmark collaboration between the Allen Institute, the University of Washington, and the Chan Zuckerberg Initiative—is engineering cells to record their histories as they divide, differentiate, and mature. Scientists can capture a complete chronicle of millions of cells at once, in whole organisms, creating datasets that will power AI models and open entirely new doors in disease research.

By engineering cells to write their own histories into their DNA, we're aiming to build the most detailed picture to date of how biology changes over a lifetime.
a landmark collaboration that will build new technologies to record the history of cells over time
synthetic biology news

Seattle Hub for Synthetic Biology launched by Allen Institute, Chan Zuckerberg Initiative, and the University of Washington will turn cells into recording devices to unlock secrets of disease
First-of-its-kind research initiative will develop technologies to reveal how changes in cells and genes over time influence human health and...

Imagine being able to put a smart watch into each of your cells to record everything that each cell is experiencing to the genome itself.
Jay Shendure
Lead Scientific Director, Seattle Hub for Synthetic Biology, Brotman Baty Institute University of Washington School of Medicine; HHMI

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synthetic biology publications
Multiplex generation and single-cell analysis of structural variants in mammalian genomes
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