Skip to main content
impact
.nav--link
research
research
impact
open science
subheadline
careers and opportunities
subheadline
people & teams
people & teams
subheadline
allen institute advisors
subheadline
board of directors
subheadline
shanahan foundation fellowship
subheadline
next generation leaders
subheadline
research
overview
our approach
subheadline
publications
subheadline
open science
subheadline
accelerator
brain science
subheadline
cell science
subheadline
neural dynamics
subheadline
immunology
subheadline
synthetic biology
subheadline
education
education
science education
subheadline
teaching resources
subheadline
field trips
subheadline
open science
subheadline
open science quest
subheadline
news
news
stories
subheadline
podcast
subheadline
sign up for our newsletter
subheadline
events
events
all events
subheadline
conferences
subheadline
event code of conduct
subheadline
events
open science quest
subheadline
summer workshop on the dynamic brain
subheadline
open science week
subheadline
brain fest
subheadline
science resources
science resources
allencell.org
subheadline
allenimmunology.org
subheadline
allenneuraldynamics.org
subheadline
brain-bican.org
subheadline
brain-map.org
subheadline
microns-explorer.org
subheadline
impact
back to menu
impact
open science
subheading
careers and opportunities
subheading
people & teams
people & teams
subheading
allen institute advisors
subheading
board of directors
subheading
shanahan foundation fellowship
subheading
next generation leaders
subheading
research
back to menu
impact
Label
subheading
Label
subheading
people & teams
education
back to menu
research
Label
subheading
Label
subheading
Heading
news
back to menu
research
Label
subheading
Label
subheading
Heading
events
back to menu
research
Label
subheading
Label
subheading
Heading
science resources
back to menu
science resources
allencell.org
subheading
allenimmunology.org
subheading
allenneuraldynamics.org
subheading
brain-bican.org
subheading
brain-map.org
subheading
microns-explorer.org
subheading
search
research
discover
synthetic biology
engineering cells and organisms to record their own histories, giving science an unprecedented look into how life unfolds.
explore synthetic biology
synthetic biology news
Scientist in purple gloves pipetting sample in modern laboratory with city view

Cells don't just exist in the present. We’re learning how to record and reconstruct everything they experience as they develop into organisms.

Traditional biology works in snapshots, capturing a frozen moment in a cell or organism's life. But disease doesn't emerge in a single moment. It's a process, unfolding over time through countless molecular and cellular decisions. To truly understand disease, you need to understand that entire process. 

The Seattle Hub for Synthetic Biology—a landmark collaboration between the Allen Institute, the University of Washington, and the Chan Zuckerberg Initiative—is engineering cells to record their histories as they divide, differentiate, and mature. Scientists can capture a complete chronicle of millions of cells at once, in whole organisms, creating datasets that will power AI models and open entirely new doors in disease research.

Scientist in white lab coat using purple pipette in bright laboratory setting with equipment
By engineering cells to write their own histories into their DNA, we're aiming to build the most detailed picture to date of how biology changes over a lifetime.

a landmark collaboration that will build new technologies to record the history of cells over time

Chan Zuckerberg Initiative
Allen Institute
University of Washington

meet our teams and partners

shendure lab
trapnell lab
pepper lab
pinglay team
hamazaki lab
write team
sense team
read team
in vivo team
SeaBridge
Brotman Baty Institute

synthetic biology news

explore more news
news 
Seattle Hub for Synthetic Biology launched by Allen Institute, Chan Zuckerberg Initiative, and the University of Washington will turn cells into recording devices to unlock secrets of disease
First-of-its-kind research initiative will develop technologies to reveal how changes in cells and genes over time influence human health and...
science images 
SciShots: A cell’s fate
Synthetic biology is helping scientists understand development
news 
A computational challenge to help developmental biology
Q&A with the scientists and organizers behind a new competition to use machine learning to reconstruct an entire animal’s developmental lineage
Imagine being able to put a smart watch into each of your cells to record everything that each cell is experiencing to the genome itself.
Jay Shendure
Lead Scientific Director, Seattle Hub for Synthetic Biology, Brotman Baty Institute University of Washington School of Medicine; HHMI
Block Quote
This is some text inside of a div block.
This is some text inside of a div block.

synthetic biology publications

view all publications
publication / 2025
Multiplex generation and single-cell analysis of structural variants in mammalian genomes
Science
publication / 2024
Revealing gene function with statistical inference at single-cell resolution
Nature Reviews. Genetics
publication / 2024
Symbolic recording of signalling and cis-regulatory element activity to DNA
Nature
view all publications

synthetic biology events

Arrow Link
No articles for the category
Arrow Link

synthetic biology advisory council

Stein Aerts
University of Leuven
Jef Boeke
NYU Langone Health
Eileen Furlong
EMBL
Dan Littman
NYU School of Medicine and HHMI
Alex Schier
University of Basel
Olga Troyanskaya
Princeton
Two scientists in white coats and purple gloves work at separate lab benches in a modern facility.

explore open positions at the allen institute

learn more
we acceleratedevelopcatalyzeimpact

science done differently. shared with the world.

explore our accelerators

brain science

Mapping every cell, connection, and circuit in the brain—openly shared with the world.

cell science

Decoding how cells become tissues, then programming that knowledge into powerful new research tools.

neural dynamics

Revealing the brain's hidden algorithms that transform neural activity into real-world behavior.

immunology

Creating the deepest open reference for the healthy human immune system ever built.

synthetic biology

Engineering cells to record their own histories, transforming how we understand disease over time.

research

Big questions, open answers, and science built to be shared.

education

Inspiring the next generation of scientists through open science resources.

impact

Our science is empowering researchers and advancing health worldwide.
advancing science through open, collaborative research
Get the allen institute newsletter
Stay informed on the latest breakthroughs in neuroscience, bioscience, and AI-driven research.
allen institute
impactpeople & teamscareers & opportunitiesalumnihistory & founder
science resources
allencell.orgallenimmunology.orgallenneuraldynamics.orgbrain-bican.orgbrain-map.orgmicrons-explorer.org
research
brain sciencecell scienceneural dynamicsimmunologysynthetic biologypublications
education
science educationfield tripsprofessional developmentteaching resources
quick links
newseventsopen sciencepodcastscience resourceshuman brain donationvisit uscontact
follow us/

allen institute, 615 Westlake Ave North, Seattle, WA 98109 +12065487055

© 0000 allen institute. all rights reserved.
privacy policyterms of usecitation policyemployee portalpolicy & compliance