goals and approach
The Hamazaki lab has pioneered a stem cell technology that models post-implantation human embryo development, simulating the differentiation of neural, renal, cardiac, somatic, and endodermal lineages. This innovative platform enables the study of complex developmental processes without the ethical concerns associated with direct embryonic studies.
Human embryo development is orchestrated by the interplay of external signals, such as morphogens, and internal genetic networks. Disruptions in these pathways can lead to various developmental diseases. We developed RA- and AP-gastruloids to model these pathologies, ranging from posterior mesodermal disorders like congenital heart defects to severe neural tube and segmentation defects like spina bifida and anencephaly.
Recording the intra- and extracellular activities during human development lays the groundwork for advancements in regenerative medicine and tissue engineering. These advancements could significantly enhance diagnostic and therapeutic strategies, mitigating congenital defects and improving quality of life.
Dr. Hamazaki is an Assistant Professor at the University of Washington’s Department of Obstetrics & Gynecology, Institute for Stem Cell & Regenerative Medicine, Department of Genome Sciences, and the Brotman Baty Institute. He also serves as a Visiting Associate Professor at Kumamoto University, in Japan. He holds a PhD, Developmental Biology and Bioinformatics from Kyoto University.
