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Jérôme Lecoq

Associate Investigator

teams /
Allenite

Jérôme Lecoq joined the Allen Institute in 2015 to lead efforts in mapping cortical computation using in vivo two-photon microscopy in behaving animals. He brings 10 years of experience in in vivo microscopy working with rodents. Prior to joining the Allen Institute, Lecoq was a postdoctoral scholar in Mark Schnitzer’s group at Stanford University, where he developed novel imaging methodologies to monitor large neuronal populations in the visual cortex of behaving mice. Lecoq received a Ph.D. in Neuroscience from the Pierre and Marie Curie University in Paris and an M.S. in Physics from ESPCI ParisTech, a French multidisciplinary engineering school.

research focus

To truly comprehend the complexities of the cortex, we must delve into its computational principles and build models that capture the essence of its workings. However, to fully test these models, we need datasets that accurately measure the neuronal representations that we seek to understand at the scale of the entire brain.As a researcher, I am passionate about building innovative platforms that revolutionize the way we understand the brain. One such platform that I have helped build and continue to develop is OpenScope, which draws inspiration from the field of astronomy to create the first brain observatory.OpenScope aims to democratize neuroscience by providing an open platform where researchers can study the brain's complex activities. Through this platform, researchers can observe how the brain responds to stimuli in real-time and create large-scale datasets that enable a deeper understanding of the brain's computational principles. The high-throughput imaging platform that I continue to improve is a crucial component of OpenScope, allowing for real-time recordings of neuronal activity and enabling a more comprehensive understanding of the brain's workings.

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featured publications

publication / 2025
Integrating multimodal data to understand cortical circuit architecture and function
Nature Neuroscience
publication / 2025
Unexpected Events Trigger Task-Independent Signaling in VIP and Excitatory Neurons of Mouse Visual Cortex
iScience
publication / 2024
Taste for discovery: a conversation with neuroscientist Serge Charpak
Neurophotonics

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news 
Scientists shoot lasers into brain cells to uncover how illusions work
Supported by the Allen Institute's OpenScope program, the findings could help us better understand neuropsychiatric disorders like schizophrenia and...
news 
World’s first crowd-sourced neuroscience study aims to understand how our brains predict the future
Using the Allen Institute’s OpenScope platform, experiments will probe brain functions related to "predictive processing"
video 
The World's Observatory of the Mind | OpenScope
Great questions can come from anywhere. OpenScope is an open platform for high-throughput and reproducible neurophysiology.

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